Research Articles

A new Cu2+-binding 1,3-benzodioxole-containing N-Acylhydrazone protects Saccharomyces cerevisiae cells from oxidative stress

Marinho-Barbosa, B.; Pires, C.D.; Galvácsi, A.; Gaudard, A. J.; Flores, L. S.; Sánchez-López, C.; Correa, C. C.; Cukierman, D.S.; Hureau, C.; Kállay, C.; Pereira, M.D.; Quintanar, L.; Rey, N. A. “A new Cu2+-binding 1,3-benzodioxole-containing N-Acylhydrazone protects Saccharomyces cerevisiae cells from oxidative stress.” ChemistrySelect 2025, 10, e202405195. https://doi.org/10.1002/slct.202405195

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Research Articles

A copper-binding peptide with therapeutic potential against Alzheimer´s disease: From the blood-brain barrier to metal competition

López-Guerrero, V.E.; Posadas, Y.; Sánchez-López, C.; Smart, A.; Miranda, J.; Singewald, K.; Bandala, Y.; Juaristi, E.; Den Auwer, C.; Perez-Cruz, C.; González-Mariscal, L.; Millhauser, G.; Segovia, J.; Quintanar, L. “A copper-binding peptide with therapeutic potential against Alzheimer´s disease: From the blood-brain barrier to metal competition” ACS Chemical Neuroscience 2025, 16, 241-261. https://doi.org/10.1021/acschemneuro.4c00796

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Research Articles

In situ detection of ferric reductase activity in the intestinal lumen of an insect

Hernández-Gallardo, A.; Arcos-López, T.; Bahena-Lopez, J.; Tejeda-Guzmán, C.; Webb, S.M Kroll, T.; Solari, P.-L.; Sánchez-López, C.; den Auwer, C.; Quintanar, L.; Missirlis, F. “In situ detection of ferric reductase activity in the intestinal lumen of an insect.”  J. Biol. Inorg. Chem. 2024, 29, 773-784. https://doi.org/10.1007/s00775-024-02080-y

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Research Articles

An N-terminal acidic β-sheet domain is responsible for the metal-accumulation properties of amyloid-β protofibrils: A molecular dynamics study

Gómez-Castro, C.Z.; Quintanar, L.; Vela, A.; “An N-terminal acidic β-sheet domain is responsible for the metal-accumulation properties of amyloid-β protofibrils: A molecular dynamics study” J. Biol. Inorg. Chem. 2024, 29, 407-425. https://doi.org/10.1007/s00775-024-02061-1

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Research Articles

An ATCUN-like copper site in 𝛽B2-crystallin plays a protective role in cataract-associated aggregation

Tovar, M.; Schuth, N.; Rodríguez-Meza, O.Kroll, T.; Saab-Rincon, G.; Costas, M.; Lampi, K.; Quintanar, L. “An ATCUN-like copper site in 𝛽B2-crystallin plays a protective role in cataract-associated aggregation” Inorg. Chem. 2023, 62, 27, 10592-10604. https://doi.org/10.1021/acs.inorgchem.3c00794

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Research Articles

Copper reductase activity and free radical chemistry by cataract-associated human lens 𝛾-crystallins

Palomino-Vizcaino, G.; Schuth, N.; Domínguez-Calva, J. A.; Rodríguez-Meza, O.; Martínez-Jurado, E.; Serebryany, E.; King, J.A.; Kroll, T.; Costas, M.; Quintanar, L. “Copper reductase activity and free radical chemistry by cataract-associated human lens 𝛾-crystallins” J. Amer. Chem. Soc. 2023, 145, 12, 6781-6797. https://doi.org/10.1021/jacs.2c13397

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Research Articles

Mercury ions impact the kinetic and thermal stabilities of human lens 𝛾-crystallins via direct metal-protein interactions

Rodríguez-Meza, O.; Palomino-Vizcaino, G.; Quintanar, L.; Costas, M. “Mercury ions impact the kinetic and thermal stabilities of human lens 𝛾-crystallins via direct metal-protein interactions” J. Inorg. Biochem. 2023, 242, 112159. https://doi.org/10.1016/j.jinorgbio.2023.112159

Mercury ions impact the kinetic and thermal stabilities of human lens 𝛾-crystallins via direct metal-protein interactions Read Post »

Research Articles

Molecular dynamics and structural studies of zinc chloroquine complexes

Paulikat, M.; Vitone, D.; Schackert F. K.; Schuth, N.; Barbanente, A.; Piccini, G.; Ippoliti, E.; Rossetti, G.; Clark, A.H.; Nachtegaal, M.; Haumann, M.; Dau, H.; Carloni, P.; Geremia, S.; De Zorzi, R.; Quintanar, L.; Arnesano, F. “Molecular dynamics and structural studies of zinc chloroquine complexes” J. Chem. Inf. Model. 2023, 63, 161-172. https://doi.org/10.1021/acs.jcim.2c01164

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Research Articles

Chloroquine disrupts zinc storage granules in primary Malpighian tubule cells of Drosophila melanogaster

Campos-Blázquez, J.P.; Schuth, N.; Garay, E.; Clark, A.H.; Vogelsang, U.; Nachtegaal, M.; Contreras, R.G.; Quintanar, L.; Missirlis, F. “Chloroquine disrupts zinc storage granules in primary Malpighian tubule cells of Drosophila melanogaster” Metallomics 2022, 14, 10, mfac075. https://doi.org/10.1093/mtomcs/mfac075

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